Diatech Pharmacogenetics

Detection of the main mutations of exons 18, 19, 20, 21 of the EGFR gene. Each mix allows the co-amplification of one or more mutated alleles plus an endogenous control gene

Detection of the main mutations of exon 2 (codons 12, 13), of exon 3 (codons 59, 61) and of exon 4 (codons 117, 146) of the KRAS gene. Each mix allows the co-amplification of one or more mutated alleles plus an endogenous control gene.

Detection of the main mutations of exon 2 (codons 12, 13), of exon 3 (codons 59, 61) and of exon 4 (codons 117, 146) of the NRAS gene. Each mix allows the co-amplification of one or more mutated alleles plus an endogenous control gene.

Detection of the main mutations of codon 600 of the BRAF gene. Each mix allows the co-amplification of one or more mutated alleles plus an endogenous control gene

EasyPGX® ready BCR-ABL p190 are in vitro diagnostics real time PCR assays for detection and quantification of BCR/ABL fusion trascripts starting from RNA extracted by pheripheral whole blood or bone marrow

EasyPGX® ready BCR-ABL p210 are in vitro diagnostics real time PCR assays for detection and quantification of BCR/ABL fusion trascripts starting from RNA extracted by pheripheral whole blood or bone marrow

EasyPGX® ready BCR-ABL Fusion (code RT038 – 48 test CE IVD) is a validated kit for in vitro diagnostic use for the qualitative detection and discrimination of BCR-ABL fusion variants in samples isolated from bone marrow, peripheral blood and leukocyte suspensions. Simultaneous detection and discrimination of the isoforms of p210, p190 and p230

“EasyPGX® ready CBFB-MYH11 Fusion” kit is an in vitro diagnostic test for the detection by One Step Real-Time PCR of CBFB-MYH11 A, D and E fusions caused by inv(16)/t(16;16).

“EasyPGX® ready AML1-ETO Fusion” kit is an in vitro diagnostic test for the detection by One Step Real-Time PCR of AML1-ETO t(8;21) fusion

“EasyPGX® ready PML-RARA Fusion“ kit is an in vitro diagnostic test for the detection by One Step Real-Time PCR of PML-RARA bcr1 (long, L-form), bcr3 (short, S-form) e bcr2 (variant, V-form) fusions.

Detection of 8 mononucleotide “quasi – monomorphic” markers: BAT-25, BAT-26, NR-21, NR-22, NR-24, NR-27, CAT-25 and MONO-27 by Real Time PCR and subsequent analysis of the targets based on the denaturation profile. The test allows, accurately and with reduced “hands-on time”, to detect the microsatellite instability in tumor samples.

Detection of the main mutations of codons 345, 420, 542, 545, 546 1047 and 1049 of the PIK3CA gene. Each mix allows the co-amplification of one or more mutated alleles plus an endogenous control gene.

Detection of the main mutations of codons 345, 420, 542, 545, 546 1047 and 1049 of the PIK3CA gene. Each mix allows the co-amplification of one or more mutated alleles plus an endogenous control gene.

Detection of the main chromosomal translocations involving ALK, ROS1, RET and the MET exon 14 skipping. Each mix allows the co-amplification of one or more fusions plus an endogenous control gene.

Detection of the main mutations of exon 2 (codons 12,13), of exon 3 (codon 61) of the KRAS, NRAS, HRAS genes and of the codons 600 and 601 of the BRAF gene. Each mix allows the co-amplification of one or more mutated alleles plus an endogenous control gene

Detection of the main mutations of exon 2 (codons 12,13), of exon 3 (codon 61) of the KRAS, NRAS, HRAS genes and of the codons 600 and 601 of the BRAF gene. Each mix allows the co-amplification of one or more mutated alleles plus an endogenous control gene

Detection of the main mutations of exon 2 (codons 12,13), of exon 3 (codon 61) of the KRAS, NRAS, HRAS genes and of the codons 600 and 601 of the BRAF gene. Each mix allows the co-amplification of one or more mutated alleles plus an endogenous control gene

Detection of the main chromosomal translocations involving ALK, ROS1, RET and the MET exon 14 skipping. Each mix allows the co-amplification of one or more fusions plus an endogenous control gene.

Detection of the main chromosomal translocations involving ALK, ROS1, RET and the MET exon 14 skipping. Each mix allows the co-amplification of one or more fusions plus an endogenous control gene.

The kit allows the manual extraction of circulating free DNA (cfDNA) from plasma. The kit Helix® Circulating Nucleic Acid, in association with the kit EasyPGX® ready EGFR, enables the mutational analysis of EGFR gene in the circulating tumour DNA (liquid biopsy) when the tumour tissue is not evaluable, according to the EMA/129677/2014 recommendations of September 25th 2014. DNA capture by silica membrane and vacuum-based system. The system to concentrate the final eluate up to 3 times is included in the kit

Identification of 14 High Risk genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68) of Human Papilloma Virus (HPV) by amplifying the E6 and E7 oncogenes. Each mix allows the co-amplification of the genotype-specific HPV targets plus an endogenous control gene.